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Recent advances in modelling cancer invasion

Organizers: Chiara Villa & Alexandre Poulain

10:40 – 11:00 – Proliferation-immuno-evasion trade off: A continuous model for tumor-immune dynamics and therapeutic strategies / Presenting author: Giulia Chiari

11:00 – 11:20 – Multiscale modelling of glioma invasion under the influence of the microenvironment / Presenting author: Martina Conte

11:20 – 11:40 – Travelling waves in heterogeneous cell populations/ Presenting author: Rebecca Crossley

11:40 – 12:00 – Hybrid modelling for cancer invasion and metastasis / Presenting author: Dimitrios Katsaounis

Brain cancer

17:20 – 17:40 – How polarisation and depolarisation affects the spreading of migrating cells / Presenting author: Christophe Deroulers.

17:40 – 18:00 – Predicting the time to relapse for individual patients with Glioblastoma for the second-line of intervention / Presenting author: Pejman Shojaee.

18:00 – 18:20 – Improving drug delivery in the brain using microbubbles combined with focused ultrasound / Presenting author: Qiyao Peng.

Mathematical models of cancer immunotherapy (II)

Organizers: Juan Belmonte Beitia​ & Álvaro Martínez Rubio​
15:00 – 15:20 -Car-T cell immunotherapy: from the bench to mathematical modeling / Presenting author: Luciana Rodrigues Carvalho Barros.

15:20 – 15:40 – Understanding the role of B cells in the treatment with CAR-T cells for acute lymphoblastics leukemia / Presenting author: Sergio Serrano.

15:40 – 16:00 – Modeling CD19 relapses after CAR-T cell therapy in B cell leukemias: Insights and implications / Presenting author: Salvador Chulián.

16:00 – 16:20 – A delayed model for tumor-immune system interactions / Presenting author: Laid Boudjellal.

Mathematical models of cancer immunotherapy (I)

Organizers: Juan Belmonte Beitia & Álvaro Martínez Rubio

10:40 – 11:00 – Computational modelling of CAR-T therapy: from pharmacokinetic description to patient-level predictions / Presenting author: Adrià Murias-Closas.

11:00 – 11:20 – Individual patient dynamics of CAR-T cell therapy in lymphoma: Model selection and response prediction / Presenting author: Álvaro Martínez-Rubio.

11:20 – 11:40 – T-cell-cancer cel conjugate dynamics impact time to equilibrium or cancer extinction / Presenting author: Qianci Yang.

11:40 – 12:00 – Modelling tumour escape mechanisms in CAR-T cell treatment of leukemias / Presenting author: Alexis Farman.

Radiotherapy in cancer

17:20 – 17:40 – A mathematical approach for tumor-associated macrophages in glioma growth and response to radiation / Presenting author: Jesús J. Bosque.

17:40 – 18:00 – A mathematical model assuming frequency-dependent cost for analyzing the influence of stem cell competition on the radiation effects / Presenting author: Kouki Uchinomiya.

18:00 – 18:20 – Efficient radial-shell model for 3D tumor spheroid dynamics with radiotherapy / Presenting author: Anja Voss-Böhme.

Multiscale mathematical models in physiological processes and cancer. From sub-cellular mechanisms to phenotype switching and metastasis (II)

Organizers: Niklas Kolbe & Zuzanna Szymanska​.

15:00 – 15:20 – Exploring the role of EMT in ovarian cancer progression and metastasis / Presenting author: Sam Oliver.

15:20 – 15:40 – A multi-layer model of cancer metastasis / Presenting author: Niklas Kolbe.

15:40 – 16:00 – Discrete and continuum modeling of robust biological transportation networks / Presenting author: Jan Haskovec.

16:00 – 16:20 – Agent-based modelling of heterogeneous EMT scenarios highlights nuclear positioning and protrusions as main drivers of extrusion / Presenting author: Steffen Plunder.

Multiscale mathematical models in physiological processes and Cancer: from sub-cellular mechanisms to phenotype switching and metastasis (I)

Organizers: Niklas Kolbe & Zuzanna Szymanska.

10:40 – 11:00 – The influence of the geometry and domain size for a reaction-diffusion system with cross-diffusion / Presenting author: Gülsemay Yiğit.

11:00 – 11:20 – Computational investigation of heterogeneous cell phenotypes in the tumour microenvironment / Presenting author: Raluca Eftimie.

11:20 – 11:40 – Cell-state transitions and frequency-dependent interactions among subpopulations together explain the dynamics of spontaneous epithelial-mesenchymal heterogeneity in breast cancer / Presenting author: Paras Jain.

11:40 – 12:00 – Modeling heterogeneous gene expression responses to TGFβ stimulation / Presenting author: Karen Amaral Oliveira

Quantitative approaches to modelling and analysing cancer-immune interactions (II)

Organizers: Eszter Lakatos & Barbara Bravi​

15:00 – 15:20 – A dynamical model of PD-1/PD-L1 and CTLA-4 immune-checkpoint therapy / Presenting author: Kamran Kaveh.

15:20 – 15:40 – Stochastic mutation rate switching in reponse to immune selection in mismatch repair-deficient colorectal cancer (MMRd CRC) / Presenting author: Lauren McKenzie.

15:40 – 16:00 – Modeling the co-evolution of an evolving cancer and T-cell repertoire: challenges and exciting opportunities for mathematics to improve T-cell immunotherapy / Presenting author: Jason T. George.

16:00 – 16:20 – The interplay between the cancer cell and the immune microenvironment during cancer / Presenting author: Nicholas McGranahan.

Quantitative approaches to modelling and analysing cancer-immune interactions (I)

Organizers: Eszter Lakatos​ & Barbara Bravi​

10:40 – 11:00 – A hybrid discrete-continuum modelling approach to explore the impact of T-Cell infiltration on anti-tumour immune response / Presenting author: Emma Leschiera

11:00 – 11:20 – Predicting T-cell receptor – peptide-MHC interactions: How can we bridge the two sides of the equations? / Presenting author: David Gfeller.

11:20 – 11:40 – Individual-based modelling of the interaction between cancer and T cells in vitro / Presenting author: Tomás Alarcón

11:40 – 12:00 – Immune evasion impacts the landscape of driver genes during cancer evolution / Presenting author: Luis Zapata Ortiz.

Mechanistic learning in mathematical oncology (II)

Organizers: Alvaro Köhn-Luque​ & Saskia Haupt​

17:00 – 17:20 – Mechanistic learning to predict the results of clinical trails / Presenting author: Sèbastien Benzekry.

17:20 – 17:40 – Patient-specific forecasting of prostate cancer growth and radiotherapy responde using biomechanistic models and hybrid classifiers / Presenting author: Guillermo Lorenzo.

17:40 – 18:00 – Augmenting mechanistic models with machine learning to predict cancer treatment outcomes / Presenting author: Álvaro Köhn-Luque

18:00 – 18:20 – On the use of neural networks for parameter identification in mathematical models of glioblastoma evolution / Presenting author: Marina Pérez-Aliacar