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Mechanistic learning in mathematical oncology (II)

Organizers: Alvaro Köhn-Luque​ & Saskia Haupt​

17:00 – 17:20 – Mechanistic learning to predict the results of clinical trails / Presenting author: Sèbastien Benzekry.

17:20 – 17:40 – Patient-specific forecasting of prostate cancer growth and radiotherapy responde using biomechanistic models and hybrid classifiers / Presenting author: Guillermo Lorenzo.

17:40 – 18:00 – Augmenting mechanistic models with machine learning to predict cancer treatment outcomes / Presenting author: Álvaro Köhn-Luque

18:00 – 18:20 – On the use of neural networks for parameter identification in mathematical models of glioblastoma evolution / Presenting author: Marina Pérez-Aliacar

Hematopoietic cancers

15:00 – 15:20 – Mathematical model of CAR-T cell therapy for a B-cell Lymphoma lymph node / Presenting author: Soukaina Sabir

15:20 – 15:40 -Understanding pre-malignant stem cell dynamics: Lessons from clonal hematopoiesis and stem cell transplantation / Presenting author:Thomas Stiehl

15:40 – 16:00 – A mathematical modeling approach to clonal architecture of hematopoietic cancers / Presenting author: Johnny Ottesen

16:00 – 16:20 – Mathematical modeling unveils optimization strategies for targeted radionucline therapy of blood cancers / Presenting author: Maxim Kuznetsov

Mechanistic learning in mathematical oncology (I)

Organizers: Alvaro Köhn-Luque & Saskia Haupt.

10:40 – 11:00 – A review of mechanistic learning in mathematical oncology. / Presenting author: Saskia Haupt.

11:00 – 11:20 – Integrating machine learning and mechanistic modeling enables non-invasive measurement of intra-tumoral fluid transport in dynamic MRI. / Presenting author: Russell Rockne.

11:20 – 11:40 – How to make clinical predictions when we do not know everything. / Presenting author: Haralampos Hatzikirou.

11:40 – 12:00 – Predicting anatomical tumor growth in pediatric glioma by guided denoising diffusion models. / Presenting author: Sarah Brüningk

Radiotherapy in cancer

17:20 – 17:40 – A mathematical approach for tumor-associated macrophages in glioma growth and response to radiation / Presenting author: Jesús J. Bosque.

17:40 – 18:00 – A mathematical model assuming frequency-dependent cost for analyzing the influence of stem cell competition on the radiation effects / Presenting author: Kouki Uchinomiya.

18:00 – 18:20 – Efficient radial-shell model for 3D tumor spheroid dynamics with radiotherapy / Presenting author: Anja Voss-Böhme.

Brain cancer

17:20 – 17:40 – How polarisation and depolarisation affects the spreading of migrating cells / Presenting author: Christophe Deroulers.

17:40 – 18:00 – Predicting the time to relapse for individual patients with Glioblastoma for the second-line of intervention / Presenting author: Pejman Shojaee.

18:00 – 18:20 – Improving drug delivery in the brain using microbubbles combined with focused ultrasound / Presenting author: Qiyao Peng.

Multiscale mathematical models in physiological processes and cancer. From sub-cellular mechanisms to phenotype switching and metastasis (II)

Organizers: Niklas Kolbe & Zuzanna Szymanska​.

15:00 – 15:20 – Exploring the role of EMT in ovarian cancer progression and metastasis / Presenting author: Sam Oliver.

15:20 – 15:40 – A multi-layer model of cancer metastasis / Presenting author: Niklas Kolbe.

15:40 – 16:00 – Discrete and continuum modeling of robust biological transportation networks / Presenting author: Jan Haskovec.

16:00 – 16:20 – Agent-based modelling of heterogeneous EMT scenarios highlights nuclear positioning and protrusions as main drivers of extrusion / Presenting author: Steffen Plunder.

Mathematical models of cancer immunotherapy (II)

Organizers: Juan Belmonte Beitia​ & Álvaro Martínez Rubio​
15:00 – 15:20 -Car-T cell immunotherapy: from the bench to mathematical modeling / Presenting author: Luciana Rodrigues Carvalho Barros.

15:20 – 15:40 – Understanding the role of B cells in the treatment with CAR-T cells for acute lymphoblastics leukemia / Presenting author: Sergio Serrano.

15:40 – 16:00 – Modeling CD19 relapses after CAR-T cell therapy in B cell leukemias: Insights and implications / Presenting author: Salvador Chulián.

16:00 – 16:20 – A delayed model for tumor-immune system interactions / Presenting author: Laid Boudjellal.

Quantitative approaches to modelling and analysing cancer-immune interactions (II)

Organizers: Eszter Lakatos & Barbara Bravi​

15:00 – 15:20 – A dynamical model of PD-1/PD-L1 and CTLA-4 immune-checkpoint therapy / Presenting author: Kamran Kaveh.

15:20 – 15:40 – Stochastic mutation rate switching in reponse to immune selection in mismatch repair-deficient colorectal cancer (MMRd CRC) / Presenting author: Lauren McKenzie.

15:40 – 16:00 – Modeling the co-evolution of an evolving cancer and T-cell repertoire: challenges and exciting opportunities for mathematics to improve T-cell immunotherapy / Presenting author: Jason T. George.

16:00 – 16:20 – The interplay between the cancer cell and the immune microenvironment during cancer / Presenting author: Nicholas McGranahan.

Multiscale mathematical models in physiological processes and Cancer: from sub-cellular mechanisms to phenotype switching and metastasis (I)

Organizers: Niklas Kolbe & Zuzanna Szymanska.

10:40 – 11:00 – The influence of the geometry and domain size for a reaction-diffusion system with cross-diffusion / Presenting author: Gülsemay Yiğit.

11:00 – 11:20 – Computational investigation of heterogeneous cell phenotypes in the tumour microenvironment / Presenting author: Raluca Eftimie.

11:20 – 11:40 – Cell-state transitions and frequency-dependent interactions among subpopulations together explain the dynamics of spontaneous epithelial-mesenchymal heterogeneity in breast cancer / Presenting author: Paras Jain.

11:40 – 12:00 – Modeling heterogeneous gene expression responses to TGFβ stimulation / Presenting author: Karen Amaral Oliveira

Recent advances in modelling cancer invasion

Organizers: Chiara Villa & Alexandre Poulain

10:40 – 11:00 – Proliferation-immuno-evasion trade off: A continuous model for tumor-immune dynamics and therapeutic strategies / Presenting author: Giulia Chiari

11:00 – 11:20 – Multiscale modelling of glioma invasion under the influence of the microenvironment / Presenting author: Martina Conte

11:20 – 11:40 – Travelling waves in heterogeneous cell populations/ Presenting author: Rebecca Crossley

11:40 – 12:00 – Hybrid modelling for cancer invasion and metastasis / Presenting author: Dimitrios Katsaounis